Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood

AIMS: Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions. METHODS: Data came from RESULTS: Most participants (90.9%) reported at least rarely having experienced some CA. Ever experiencing each CA other than emotional neglect was univariably associated with 3-month APNS (RRs = 1.31-1.60). Each CA frequency was also univariably associated with 3-month APNS (RRs = 1.65-2.45). In multivariable models, joint associations of CAs with 3-month APNS were additive, with frequency of emotional abuse (RR = 2.03; 95% CI = 1.43-2.87) and bullying (RR = 1.44; 95% CI = 0.99-2.10) being the strongest predictors. Control variable analyses found that these associations were largely explained by pre-MVC histories of PTSD and MDE. CONCLUSIONS: Although individuals who experience frequent emotional abuse and bullying in childhood have a heightened risk of experiencing APNS after an adult MVC, these associations are largely mediated by prior histories of PTSD and MDE

Speech Communication

Contains reports on six research projects.U. S. Air Force Command and Control Development Division under Contract AF19(604)-6102National Science Foundatio

Perceptions of knowledge sharing among small family firm leaders: a structural equation model

Small family firms have many unique relational qualities with implications for how knowledge is passed between individuals. Extant literature posits leadership approach as important in explaining differences in knowledge-sharing climate from one firm to another. This study investigates how leadership approaches interact with family influence to inform perceptions of knowledge sharing. We utilize survey data (n = 110) from owner-managers of knowledge-intensive small family firms in Scotland. Our findings present a choice in leadership intention, contrasting organization-focused participation against family-influenced guidance. Insight is offered on the implications of this leadership choice at both organizational and familial level

Speech Communication

Contains research objectives and reports on two research projects.U.S. Air Force (Electronic Systems Division) under Contract AF19(604)-6102National Science Foundation (Grant G-10800)National Science Foundation (Grant G-7364)National Science Foundation (Grant G-16526)National Institutes of Health (Grant MP-4737

Bimodal release ondansetron for acute gastroenteritis among adolescents and adults: A randomized clinical trial

Importance: Vomiting resulting from acute gastroenteritis is commonly treated with intravenous antiemetics in acute care settings. If oral treatment were beneficial, patients might not need intravenous administered hydration or medication. Furthermore, a long-acting treatment could provide sustained relief from nausea and vomiting. Objective: To determine whether an experimental long-acting bimodal release ondansetron tablet decreases gastroenteritis-related vomiting and eliminates the need for intravenous therapy for 24 hours after administration. Design, Setting, and Participants: This placebo-controlled, double-blind, randomized clinical trial included patients from 19 emergency departments and 2 urgent care centers in the United States from December 8, 2014, to February 17, 2017. Patients 12 years and older with at least 2 vomiting episodes from presumed gastroenteritis in the previous 4 hours and symptoms with less than 36 hours\u27 duration were randomized using a 3:2 active to placebo ratio. Analyses were performed on an intent-to-treat basis and conducted from June 1, 2017, to November 1, 2017. Intervention: Bimodal release ondansetron tablet containing 6 mg of immediate release ondansetron and 18 mg of a 24-hour release matrix for a total of 24 mg of ondansetron. Main Outcomes and Measures: Treatment success was defined as no further vomiting, no need for rescue medication, and no intravenous hydration for 24 hours after bimodal release ondansetron administration. Results: Analysis included 321 patients (mean [SD] age, 29.0 [11.1] years; 195 [60.7%] women), with 192 patients in the bimodal release ondansetron group and 129 patients in the placebo group. Treatment successes were observed in 126 patients in the bimodal release ondansetron group (65.6%) compared with 70 patients in the placebo group (54.3%), with an 11.4% (95% CI, 0.3%-22.4%) absolute probability difference. The proportion of treatment success was 21% higher among patients who received bimodal release ondansetron compared with those who received a placebo (relative risk, 1.21; 95% CI, 1.00-1.46; P = .04). In an analysis including only patients with a discharge diagnosis of acute gastroenteritis and no major protocol violations, there were 123 treatment successes (69.5%) in the bimodal release ondansetron group compared with 67 treatment successes (54.9%) in the placebo group (relative risk, 1.27; 95% CI, 1.05-1.53; P = .01). Adverse effects were infrequent and similar to the known safety profile of ondansetron. Conclusions and Relevance: This randomized clinical trial found that a long-acting bimodal release oral ondansetron tablet was an effective antiemetic among adolescents and adults with moderate to severe vomiting from acute gastroenteritis. The drug benefits extended to 24 hours after administration. Bimodal release ondansetron may decrease the need for intravenous access and emergency department care to manage acute gastroenteritis. Trial Registration: ClinicalTrials.gov identifier: NCT02246439

Rotation Measure Synthesis of Galactic Polarized Emission with the DRAO 26-m Telescope

Radio polarimetry at decimetre wavelengths is the principal source of information on the Galactic magnetic field. The diffuse polarized emission is strongly influenced by Faraday rotation in the magneto-ionic medium and rotation measure is the prime quantity of interest, implying that all Stokes parameters must be measured over wide frequency bands with many frequency channels. The DRAO 26-m Telescope has been equipped with a wideband feed, a polarization transducer to deliver both hands of circular polarization, and a receiver, all operating from 1277 to 1762 MHz. Half-power beamwidth is between 40 and 30 arcminutes. A digital FPGA spectrometer, based on commercially available components, produces all Stokes parameters in 2048 frequency channels over a 485-MHz bandwidth. Signals are digitized to 8 bits and a Fast Fourier Transform is applied to each data stream. Stokes parameters are then generated in each frequency channel. This instrument is in use at DRAO for a Northern sky polarization survey. Observations consist of scans up and down the Meridian at a drive rate of 0.9 degree per minute to give complete coverage of the sky between declinations -30 degree and 90 degree. This paper presents a complete description of the receiver and data acquisition system. Only a small fraction of the frequency band of operation is allocated for radio astronomy, and about 20 percent of the data are lost to interference. The first 8 percent of data from the survey are used for a proof-of-concept study, which has led to the first application of Rotation Measure Synthesis to the diffuse Galactic emission obtained with a single-antenna telescope. We find rotation measure values for the diffuse emission as high as approximately 100 rad per square metre, much higher than recorded in earlier work.Comment: Accepted for publication in The Astronomical Journa

Aqueous Processes and Microbial Habitability of Gale Crater Sediments from the Blunts Point to the Glenn Torridon Clay Unit

A driving factor for sending the Mars Science Laboratory, Curiosity rover to Gale Crater was the orbital detection of clay minerals in the Glen Torridon (GT) clay unit. Clay mineral detections in GT suggested a past aqueous environment that was habitable, and could contain organic evidence of past microbiology. The mission of the Sample Analysis at Mars (SAM) instrument onboard Curiosity was to detect organic evidence of past microbiology and to detect volatile bearing mineralogy that can inform on whether past geochemical conditions would have supported microbiological activity. The objective of this work was to 1) evaluate the depositional/alteration conditions of Blunts Point (BP) to GT sediments 2) search for evidence of organics, and 3) evaluate microbial habitability in the BP, Vera Rubin Ridge (VRR), and GT sedimentary rock

Sorghums in the post-rainy season. I. Effect of irrigation and date of sowing on the grain and stover yields of diverse cultivars

In India, sorghum is grown during the post-rainy season on Vertisols with stored soil moisture. As water stress towards the end of the growing season is believed to be a major cause of poor yields in these crops, an experiment was carried out involving five sorghum genotypes and four sowing dates with and without irrigation. Supplementary irrigation with 40 mm of water in the earliest sown crop increased grain yields by 24 and 26% in 1979 and 1982, respectively, while irrigation with a total of 120mm water in the latest sown crop increased yields by 87 and 60% compared with the corresponding dryland crops. Early sowings always resulted in better stover and grain yields irrespective of irrigation treatment. Grain yields of hybrids were similar to those of the cultivars but their stover yields were less. The post-rainy season cultivar SPY 86 gave the best grain yield across sowing dates. The widely grown post-rainy season cultivar M 35–1 yielded less but produced more stover and its yields were more stable. The importance of the stability of grain and stover yields and of evaluating the materials for more than one date of sowing in selecting sorghums for the post-rainy season is discussed

Thermal activation between Landau levels in the organic superconductor β′′\beta''-(BEDT-TTF)2_{2}SF5_{5}CH2_{2}CF2_{2}SO3_{3}

We show that Shubnikov-de Haas oscillations in the interlayer resistivity of the organic superconductor $\beta''$-(BEDT-TTF)$_{2}$SF$_{5}$ CH$_{2}$CF$_{2}$SO$_{3}$ become very pronounced in magnetic fields $\sim$~60~T. The conductivity minima exhibit thermally-activated behaviour that can be explained simply by the presence of a Landau gap, with the quasi-one-dimensional Fermi surface sheets contributing negligibly to the conductivity. This observation, together with complete suppression of chemical potential oscillations, is consistent with an incommensurate nesting instability of the quasi-one-dimensional sheets.Comment: 6 pages, 4 figure

Combining ability and heterosis for diastatic activity in grain sorghum

Eighty-five sorghum (Sorghum bicolor (L.) Moench) entries including 13 restorer-lines (lines), 5 maintainer-lines (testers), 65 F1 hybrids, and two controls, were grown at Muzarabani, Zimbabwe during the rainy seasons of 1986/87 and 1987/88 to study the combining ability and heterosis for diastatic activity. Grain samples were evaluated for diastatic activity, expressed in Sorghum Diastatic Units (SDU) per gram of malt, in 1989. Differences between sorghum lines, testers, hybrids, and total entries were significant for diastatic activity in both seasons. There were large differences in mean diastatic activity values and ranges for entries in both seasons. The mean SDU g-1 malt for hybrids varied from 20.5 to 67.2 for the 1986/87 season and 13.3 to 48.9 for the 1987/88 season. Variation in diastatic activity was primarily due to non-additive gene action. The highest positive general combining ability effects were observed for the line 4HA85S, and tester 120A. Significant positive specific combining ability effects were observed for hybrid 120A x D 38073-2. This was the only cross which had positive high parent heterosis in both seasons, but it was only significant in the 1987/88 season. Most of the crosses had negative high parent heterosis. To improve diastatic activity, recurrent selection procedures for specific combining ability should be used to develop elite parents for hybrid